第二季揭开了驱魔人系列故事的篇章，第一集于美国时间2017年9月29日（星期五）播出。托马斯神父和被驱逐出教会的马科斯离开芝加哥上路寻找恶魔。大洋彼岸，本内特神父试图找出梵蒂冈内部背弃上帝的内奸。最终，托马斯和马科斯找到了安德鲁·金，他曾是一名儿童心理医生，如今在西雅图离岸的一座私人隐居的小岛上照管一个5个边缘寄养儿童之家。当其中一个孩子被强大的恶魔锁定，两位神父一路向西将与来自地狱一场恶战。
　　Opening an entirely new chapter in the iconic franchise, Season Two of THE EXORCIST premieres Friday, September 29 (9:00 - 10:00 PM PT/ET), where FATHER TOMAS ORTEGA (Alfonso Herrera) and a newly collarless MARCUS KEANE (Ben Daniels) out of Chicago and on the road, searching out evil. Across the Atlantic, FATHER BENNETT (Kurt Egyiawan) attempts to weed out those within the Vatican who have turned against God. Ultimately, Tomas and Marcus are led to ANDREW KIM (John Cho), a former child psychologist who runs a group home for five at-risk foster children on a secluded private island off the coast of Seattle. When one of the children under Andrew’s care is targeted by a powerful force, the two priests head west, setting themselves on a collision course with Hell.